It is also on a 15-6 roll on top-rated NFL picks since Week 7 of this season. The model enters the Super Wild Card Weekend in the 2023 NFL playoffs on an incredible 161-113 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. 49ers picks, make sure you check out the latest NFL predictions and betting advice from SportsLine's proven projection model. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 42. San Francisco is a 9.5-point favorite in the latest 49ers vs. Kickoff from Levi's Stadium is set for 4:30 p.m. It's the first game of the NFL playoffs 2023. The Seahawks (9-8) have lost four of their last five postseason contests, but defeated the 49ers in their only previous playoff encounter, as they posted a 23-17 home victory in the 2013 NFC Championship Game. San Francisco (13-4), which is riding a 10-game winning streak, swept the two-game season series with Seattle after losing the previous four meetings between the clubs. The NFC West champion San Francisco 49ers will try to complete the hat trick when they host the division-rival Seattle Seahawks in a 2023 NFL Super Wild Card Weekend game on Saturday.